Evidence map›Paper›PMID 42758816›Full record

ArticleScience advances2026

Super-enhancer-driven SGK1 activates polyamine metabolism to promote autoimmune uveitis.

He Li, Lei Zhu, Zhaohuai Li, Genxian Zhang, Gengchen Jiang, Yihan Zhang, Jialing Tang, Xuling Chen, Yingying Wen, Shenqian Tian and 7 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

He LiState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0007-7279-788X
Lei ZhuState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0001-2283-196X
Zhaohuai LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.ORCID 0000-0002-9071-6031
Genxian ZhangState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0003-7454-2347
Gengchen JiangState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0003-9190-1145
Yihan ZhangState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0003-3114-5368
Jialing TangState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0007-8602-1265
Xuling ChenState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0000-0001-6885-9864
Yingying WenBengbu Medical University, Bengbu 233000, China.ORCID 0009-0006-1142-1259
Shenqian TianBengbu Medical University, Bengbu 233000, China.ORCID 0009-0004-8868-9320
Siyun LiuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.ORCID 0009-0003-2575-8264
Yue PengSchool of Clinical Medicine, Qinghai University, Xining 810000, China.ORCID 0000-0002-0506-6362
Qi JiangState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0001-6363-7266
Xingyu LiuState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0009-0004-1005-2418
Lian HanBengbu Medical University, Bengbu 233000, China.ORCID 0009-0008-9515-1392
Renbing JiaState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0000-0001-6642-7451
Wenru SuState Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.ORCID 0000-0002-0506-6362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveitis, a leading cause of blindness, is driven by dysregulated immune responses, particularly autoreactive T cells. Despite advances in understanding its pathogenesis, key regulatory mechanisms remain elusive. Here, we integrate the cleavage under targets and tagmentation (CUT&Tag) and single-cell RNA sequencing (scRNA-seq) to delineate the super-enhancer (SE) landscape and transcriptional profiles of CD4

Indexed as

Autoimmune DiseasesEnhancer Elements, GeneticImmediate-Early ProteinsPolyaminesProtein Serine-Threonine KinasesUveitisAnimalsHumansMiceSerum-Glucocorticoid Regulated KinasesTh17 CellsT-Lymphocytes, RegulatoryImmediate-Early ProteinsPolyaminesProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated Kinases

Identifiers

PMID42758816
PMCPMC13588175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.