Evidence map›Paper›PMID 42758655›Full record

ArticleGut microbes2026

IgA deficiency reveals a microbiota-dependent pathway to gluten sensitivity.

Ryan A W Ball, Ahmed D Mohammed, Amy Jolly, Kenny Johnson, Summer Sklenicka, Melana Kucherina, Tori Peacock, Evan Liu, Kristen M Hogan, Maredith Baird and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ryan A W BallDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Ahmed D MohammedDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Amy JollyDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Kenny JohnsonDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Summer SklenickaDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Melana KucherinaDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Tori PeacockDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Evan LiuDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Kristen M HoganDepartment of Biological Sciences, University of South Carolina, Columbia, SC, USA.
Maredith BairdDepartment of Biological Sciences, University of South Carolina, Columbia, SC, USA.
Maria Marjorette O PeñaDepartment of Biological Sciences, University of South Carolina, Columbia, SC, USA.
Prakash NagarkattiDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Mitzi NagarkattiDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Jason L KubinakDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
B-cell-intrinsic MHCII Signaling is a Diversifying Force of Selection on IgA Repertoires and the Gut MicrobiotaR01AI155887 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KUBINAK, JASON L · 2021 to 2025
$2.1M
BD FACSymphony A5 Cell AnalyzerS10OD032271 · OD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KUBINAK, JASON L, PRICE, ROBERT L · 2022 to 2022
$513k
NIAID NIH HHS R01 AI155887NIGMS NIH HHS P20 GM103499NIH HHS S10 OD032271
6 · The paper itself

Abstract

Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency and increases susceptibility to gluten-related enteropathies, but the underlying mechanisms of pathogenesis are unknown. Utilizing IgA

Indexed as

Celiac DiseaseGastrointestinal MicrobiomeGlutensIgA DeficiencyAnimalsBacteriaDiet, Gluten-FreeIleumImmunoglobulin AIntestinal MucosaIntestine, SmallMiceMice, Inbred C57BLMice, KnockoutTh17 CellsGlutensImmunoglobulin Agluten sensitivityIgA deficiencyImmunologymicrobiomemucosal immunologysmall intestinestreptococcus

Identifiers

PMID42758655
PMCPMC13596903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.