ArticleSTAR protocols2026
Protocol for identifying cellular and molecular signatures from spatial profiling data using micro-tissue analysis.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Spatial tissue profiling measures hundreds to thousands of biomolecules across tissue regions, but most analyses examine each feature one at a time. Here, we present a protocol for micro-tissue analysis using partial least-squares modeling. We describe steps for stratifying regions by microenvironment, building multivariate models to identify which features collectively drive a biological outcome, and interpreting the results. We detail four worked examples using two published GeoMx digital spatial profiler (DSP) datasets from human tumor and mucosal tissues. For complete details on the use and execution of this protocol, please refer to Lu et al.
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