Evidence map›Paper›PMID 42758460›Full record

ArticleInternational journal of hematology2026

Dynamic nutritional changes between relapse and second allogeneic transplantation predict survival in acute leukemia.

Kodai Hasegawa, Takuya Miyazaki, Masatsugu Tanaka, Maki Hagihara, Shota Arai, Natsuki Hirose, Jun Nukui, Akihiko Izumi, Jun Aoki, Yuki Nakajima and 3 more

Abstract read
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Article in International journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Kodai HasegawaDepartment of Hematology, Yokohama City University Medical Center, 4-57, Urafune-Cho, Minami-Ku, Yokohama, Kanagawa, 232-0024, Japan.
Takuya MiyazakiDepartment of Hematology, Yokohama City University Medical Center, 4-57, Urafune-Cho, Minami-Ku, Yokohama, Kanagawa, 232-0024, Japan. takuya_m@yokohama-cu.ac.jp.ORCID http://orcid.org/0000-0003-1884-4757
Masatsugu TanakaDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Maki HagiharaDepartment of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan.
Shota AraiDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Natsuki HiroseDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Jun NukuiDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Akihiko IzumiDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Jun AokiDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Yuki NakajimaDepartment of Hematology, Yokohama City University Medical Center, 4-57, Urafune-Cho, Minami-Ku, Yokohama, Kanagawa, 232-0024, Japan.
Takayoshi TachibanaDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Shin FujisawaDepartment of Hematology, Yokohama City University Medical Center, 4-57, Urafune-Cho, Minami-Ku, Yokohama, Kanagawa, 232-0024, Japan.
Hideaki NakajimaDepartment of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relapse after a first allogeneic hematopoietic stem cell transplantation (HSCT1) remains a major therapeutic challenge in acute leukemia, and second transplantation (HSCT2) is frequently considered for selected patients. Although pre-transplant nutritional status has been associated with outcomes after HSCT2, the prognostic significance of changes in nutritional status between relapse and HSCT2 remains unclear. This multicenter retrospective study analyzed 67 patients with acute myeloid leukemia or acute lymphoblastic leukemia who underwent HSCT2 after relapse following HSCT1. Nutritional status was evaluated using serum albumin, Geriatric Nutritional Risk Index (GNRI), and body mass index (BMI) at relapse and before HSCT2. In multivariate analysis, declines in serum albumin and GNRI during this interval were independently associated with inferior overall survival, whereas BMI decline was not significant. Declines in albumin and GNRI were significantly associated with impaired performance status, but not associated with disease status at HSCT2 or treatment intensity after relapse. A composite model integrating nutritional decline and disease status at HSCT2 stratified patients into distinct prognostic groups. These findings suggest that declines in nutrition-associated indices during the relapse-to-HSCT2 interval may reflect impaired physiological reserve and provide additional prognostic information beyond disease status at transplantation.

Indexed as

Acute leukemiaNutritional statusPrognostic factorSecond allogeneic hematopoietic stem cell transplantation

Identifiers

PMID42758460

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.