ArticleAnnals of surgical oncology2026
Real-World Clinical, Enviro-Logistical and Economic Implications of Sentinel Lymph Node Biopsy Omission in Early Breast Cancer.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe randomized INSEMA, SOUND, and BOOG 2013-08 trials demonstrated oncologic non-inferiority of omitting sentinel lymph node biopsy (SLNB) for selected patients with biologically favorable early breast cancer (eBC). However, real-world implementation and the associated clinical, economic, and environmental implications remain unclear.
methodsA retrospective cohort study analyzed patients with eBC treated at a certified tertiary breast cancer center (2018-2020). Eligibility for SLNB omission was determined according to current guidelines (cT1, cN0, HR+/HER2-, grades 1 and 2, age ≥ 50 years). Clinical upstaging rates were assessed. Time toxicity was derived from prospectively collected nuclear medicine workflow data. Environmental impact was quantified using a process-based carbon footprint analysis of 99mTc-guided SLNB. Economic implications were modeled within the German diagnosis-related-groups-reimbursement framework. National extrapolations were performed using registry incidence data.
resultsOf 885 patients, 248 (28%) fulfilled the omission criteria. Postoperative upstaging to ≥ pT2 occurred for 14.9% and to pN+ for 13.3% of the patients, with no significant difference between lobular and no-special-type subtypes (p = 0.31). Marking of SLNB resulted in 2.18 h of additional patient time burden, and associated waste generated 0.54 kg of CO
conclusionsNearly one third of patients with eBC qualify for SLNB omission according to current guidelines. Beyond oncologic safety, this strategy reduces patient time toxicity, environmental burden, and resource utilization, supporting axillary de-escalation as a model of sustainable and value-based surgical oncology.
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