Evidence map›Paper›PMID 42758390›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Antileishmanial activity of gold(I) compounds containing triphenylphosphine ligands against Leishmania amazonensis: impacts on mitochondrial bioenergetics and trypanothione reductase activity.

Marcus Sávio Araujo Garcia, Vitor Klipel da Silva Bertolini, Cécile Exertier, Fernanda Ramos Gadelha, Andrea Ilari, Annarita Fiorillo, Jennyfer Castro, Camilla Abbehausen, Danilo Ciccone Miguel

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcus Sávio Araujo GarciaInstitute of Biology, University of Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6338-1929
Vitor Klipel da Silva BertoliniInstitute of Biology, University of Campinas, São Paulo, Brazil.ORCID http://orcid.org/0009-0001-0562-5080
Cécile ExertierDepartment of Biochemical Sciences, Institute of Molecular Biology and Pathology (IBPM) of the National Research Council of Italy (CNR), Sapienza University of Rome, 00185, Roma, Italy.ORCID http://orcid.org/0000-0001-7457-6895
Fernanda Ramos GadelhaInstitute of Biology, University of Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1075-8830
Andrea IlariDepartment of Biochemical Sciences, Institute of Molecular Biology and Pathology (IBPM) of the National Research Council of Italy (CNR), Sapienza University of Rome, 00185, Roma, Italy.ORCID http://orcid.org/0000-0002-7754-399X
Annarita FiorilloDepartment of Biochemical Sciences, Sapienza University of Rome, 00185, Roma, Italy.ORCID http://orcid.org/0000-0002-8966-8554
Jennyfer CastroInstitute of Chemistry, University of Campinas, Campinas, São Paulo, Brazil.ORCID http://orcid.org/0009-0001-5045-8947
Camilla AbbehausenInstitute of Chemistry, University of Campinas, Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-8410-2252
Danilo Ciccone MiguelInstitute of Biology, University of Campinas, São Paulo, Brazil. dcmiguel@unicamp.br.ORCID https://orcid.org/0000-0003-0522-6562

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 140502/2024-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 304587/2022-2Conselho Nacional de Desenvolvimento Científico e Tecnológico #314811/2021-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 88887.713008/2022-00; 88881.982693/ 2024-01Fundação de Amparo à Pesquisa do Estado de São Paulo #14/21129-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/02618-0Fundação de Amparo à Pesquisa do Estado de São Paulo #2025/01266-1National Collection of Chemical Compounds and Screening Center DSB.AD011.013.001)NextGenerationEU IR0000009
6 · The paper itself

Abstract

Leishmaniasis poses a significant public health challenge, highlighting the urgent need for safer and more effective therapies. Here, we investigated the antileishmanial activity and mechanism of action of gold(I)-triphenylphosphine complexes against Leishmania amazonensis. AuPPh

Indexed as

GoldIn vitroLeishmanicidalTriphenylphosphineTrypanothione reductase

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.