Evidence map›Paper›PMID 42758386›Full record

ArticleDigestive diseases and sciences2026

Frequent Use of Restricted Oral Intake During Hospitalization for IBD Flares Was Not Associated with Improved Clinical Outcomes: A Multicenter Retrospective Cohort Study.

Vincent Phan, Natalie Malluru, Jonathan Espinoza, Ariel Hurwitz, Tarushi Tanaya, Chandershekhar Shori, Clara DiVincenzo, Zhouwen Tang, Linda A Feagins

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Vincent PhanDepartment of Medicine, Dell Medical School at The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA.
Natalie MalluruDepartment of Medicine, Dell Medical School at The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA.
Jonathan EspinozaDepartment of Medicine, Dell Medical School at The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA.
Ariel HurwitzDepartment of Medicine, Dell Medical School at The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA.
Tarushi TanayaDepartment of Medicine, Dell Medical School at The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA.
Chandershekhar ShoriUniversity of Central Florida College of Medicine, Orlando, FL, USA.
Clara DiVincenzoDivision of Gastroenterology, Dell Medical School at The University of Texas at Austin, Austin, TX, USA.
Zhouwen TangDepartment of Medicine, Dell Medical School at The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA.
Linda A FeaginsDepartment of Medicine, Dell Medical School at The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA. linda.feagins@austin.utexas.edu.ORCID http://orcid.org/0000-0001-7758-3257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are limited indications for bowel rest in hospitalized patients with inflammatory bowel disease (IBD) flares, particularly in patients with only inflammatory disease (i.e., no obstruction, abscess, or fistula). We aimed to assess the frequency of restricted oral intake and its impact on IBD-related outcomes.

methodsPatients hospitalized with flares between 2015 and 2020 in a large urban multi-hospital network were included. Patients with obstruction, active intra-abdominal abscess or fistula, elective surgery, or new IBD diagnoses were excluded. Restricted oral intake, defined as time spent nil per os (NPO) or on a clear liquid diet (CLD), was calculated as a proportion of total hospital stay and analyzed by quartiles.

resultsA total of 315 patients (137 CD, 174 UC, 4 IBDU) were included. Most patients (90.1%) had at least one period of restricted oral intake, accounting for a mean of 35.4% of hospitalization. There were no significant differences across quartiles in 30-day or 90-day readmission, unplanned surgery, or inpatient biologic use. Similar findings were observed in subgroup analyses of Crohn's disease and ulcerative colitis.

conclusionRestricted oral intake is common among hospitalized patients with IBD flares and accounts for a substantial proportion of hospitalization time. Increased duration of restricted oral intake was not associated with improved clinical outcomes. These findings support current guideline recommendations that routine dietary restriction in the absence of clear indications should be reconsidered.

Indexed as

Crohn’s diseaseFastingInflammatory bowel diseaseUlcerative colitis

Identifiers

PMID42758386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.