In one paragraphArticle in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
24 authors.
Dovran Ovezgeldiyev *Helminth Immunology, Department of Swiss Tropical and Public Health Institute, Allschwill, Switzerland.ORCID 0009-0005-4536-9826 Vanessa Trefzer *Helminth Immunology, Department of Swiss Tropical and Public Health Institute, Allschwill, Switzerland.ORCID 0009-0005-5900-9186 Rory Doolan *Laboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, Australia.ORCID 0000-0001-9592-7607 Mati MoyatLaboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, Australia.ORCID 0000-0002-9233-5320 Gillian CoakleyLaboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, Australia.ORCID 0000-0002-4628-7890 Lakshanie C WickramasingheLaboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, Australia.ORCID 0000-0001-8733-2945 Carmel DauntLaboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, Australia.ORCID 0009-0000-3890-9699 Beatrice VolpeGlobal Health Institute, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne, Switzerland.ORCID 0009-0000-8423-5584 Fiona HenkelCenter of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich , Munich, Germany.ORCID 0000-0003-3198-2046 Alex SerraHelminth Immunology, Department of Swiss Tropical and Public Health Institute, Allschwill, Switzerland.ORCID 0009-0008-2093-8502 Maike HartmannHelminth Immunology, Department of Swiss Tropical and Public Health Institute, Allschwill, Switzerland.ORCID 0009-0003-6673-8382 Shirin RezaeiHelminth Immunology, Department of Swiss Tropical and Public Health Institute, Allschwill, Switzerland.ORCID 0009-0009-8097-1790 Niki UbagsFaculty of Biology and Medicine, Service de Pneumologie, CHUV, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0002-0177-4134 Alana ButlerDepartment of Immunology, School of Translational Medicine Monash University, Melbourne, Australia.ORCID 0000-0003-2122-2975 Roxanne ChatzisDepartment of Immunology, School of Translational Medicine Monash University, Melbourne, Australia.ORCID 0009-0005-8387-0881 Benjamin J MarslandFaculty of Biology and Medicine, Service de Pneumologie, CHUV, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0003-1457-3160 Adam Alexander T SmithFriedrich Miescher Institute for Biomedical Research (FMI) , Basel, Switzerland.ORCID 0000-0003-4593-3042 Kathrina J BingerDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.ORCID 0000-0003-1139-3308 Malcolm J McConvilleDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.ORCID 0000-0002-7107-7887 Julia Esser-von Bieren *Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich , Munich, Germany.ORCID 0000-0003-1898-9382 Nicola L Harris *Laboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, Australia.ORCID 0000-0003-2922-0210 Tiffany Bouchery *Laboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, Australia.ORCID 0000-0003-3743-7356 Funding
German Research Foundation ES 471/3-2German Research Foundation ES 471/6-1German Research Foundation FOR2599German Research Foundation SPP2306Monash Platform Access PAG19-0569National Health and Medical Research CouncilSwiss National Science Foundation 310030_212312Swiss National Science Foundation PR00P3_193084Swiss National Science Foundation SNF310030_156517
6 · The paper itselfAbstract
Macrophage polarization by type-2 cytokines is central to anti-helminth immunity and tissue repair. While some hallmark changes in macrophages are well-characterized and associated with protection against helminths, it is still unclear how macrophages exert their anti-helminth effects. In this context, we investigated arachidonate 15-lipoxygenase (LOX) (Alox15), a LOX well known for its role in macrophage polarization in the context of metabolic diseases, and a hallmark of type-2 macrophage (M2) human polarization. We show that in the absence of Alox15, M2 cannot trap and kill helminths. Surprisingly, expression of M2 markers was normal despite a loss of function. Instead, we found a concomitant increase in pro-inflammatory responses due to an uncontrolled activation of glycolysis. We further show that activation of Peroxisome proliferator-activated receptor-delta (PPAR-δ) by lipids downstream of docosapentaenoic acid (DPA) can restore normal glycolysis control, highlighting a novel role of lipids in the fine-tuning of the metabolic support required for optimal macrophage polarization.
Indexed as
Arachidonate 15-LipoxygenaseGlycolysisMacrophagesAnimalsHumansMacrophage ActivationALOX15 protein, humanArachidonate 15-Lipoxygenase
Identifiers
PMID42758314
PMCPMC7619611
What OpenQuestion holds
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