Evidence map›Paper›PMID 42758261›Full record

ReviewNeuroscience bulletin2026

Small-Conductance Ca

Renjun Wang, Zhengwei Li, Andrew D Chapp, Min Lin, Dong-Shu Du, Zhiying Shan, Zixi Jack Cheng, Qing-Hui Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renjun WangDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping, 136000, China.
Zhengwei LiDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping, 136000, China.
Andrew D ChappDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931-1200, USA.
Min LinDepartment of Neuroscience, Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, 32611, USA.
Dong-Shu DuSchool of Life Sciences, Shanghai University, Shanghai, 200444, China.
Zhiying ShanDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931-1200, USA.
Zixi Jack ChengBiomolecular Science Center, College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32816, USA. Zixi.Cheng@ucf.edu.
Qing-Hui ChenDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931-1200, USA. qinghuic@mtu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dyshomeostasis of the autonomic nervous system (ANS) drives chronic illnesses including hypertension, heart failure, diabetes mellitus, metabolic syndrome, Parkinson's disease, and traumatic brain injury. Abnormal neuronal excitability within central nervous system (CNS) nuclei is a major cause of ANS dysfunction. Small-conductance calcium-activated potassium (SK) channels govern excitability in central autonomic nuclei, sustaining neuronal excitation-inhibition balance via medium afterhyperpolarization potentials (mAHP)-mediated negative feedback. This review describes SK channels' molecular structure and electrophysiology, maps central sympathetic-parasympathetic neuroanatomical pathways, and highlights pathological impacts of the dysfunction of SK channels among the hypothalamic paraventricular nucleus (PVN) and nucleus ambiguus (NA). It also summarizes SK channels-centered regulatory approaches: epigenetics (DNA methylation, miRNA modulation), post-translational modification (phosphorylation, ubiquitination), protein interaction, metabolites, and synthetic exogenous agonists and antagonists. These results offer a theoretical basis and candidate targets to decode the neurogenic hypertension and diabetes mechanisms and facilitate bench-to-clinic translation.

Indexed as

Autonomic nervous systemHypertensionHypothalamic paraventricular nucleusNeonatal mice of diabetic mothersNucleus ambiguusSK channels

Identifiers

PMID42758261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.