Evidence map›Paper›PMID 42758238›Full record

ArticleLa Radiologia medica2026

Early post-transplant ventilation and perfusion assessment using phase-resolved functional lung MRI.

Marc-Luca Heinze, Fabio Ius, Andreas Voskrebenzev, Till Kaireit, Marius Klein, Arjang Ruhparwar, Jawad Salman, Frank Wacker, Jens Vogel-Claussen, Gesa H Pöhler

Abstract read
PubMed Publisher
In one paragraph

Article in La Radiologia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marc-Luca Heinze *Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0009-0004-3939-3590
Fabio Ius *Department of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-8084-3360
Andreas VoskrebenzevDepartment of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0001-5699-1841
Till KaireitDepartment of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0003-4007-4904
Marius KleinDepartment of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0001-6956-0733
Arjang RuhparwarDepartment of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0003-2725-9912
Jawad SalmanDepartment of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-7172-2946
Frank WackerDepartment of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-6285-8403
Jens Vogel-ClaussenDepartment of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0001-5595-6948
Gesa H PöhlerDepartment of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. gesa.poehler@ukmuenster.de.ORCID http://orcid.org/0000-0002-3994-1495

Funding

Gesellschaft der Freunde der Medizinischen Hochschule Hannover 79201005
6 · The paper itself

Abstract

purposePost-transplant functional lung surveillance relies on global ventilatory assessment using spirometry, lacking regional ventilation and perfusion measures. We aimed to assess early post-transplant lung function in clinically stable recipients using phase-resolved functional lung (PREFUL) MRI. MATERIAL AND

methodsIn this prospective, single-center study (March 2022-December 2024), clinically stable bilateral lung transplant recipients and 1:1 age- (± 5 years) sex-matched participants (n = 100) underwent PREFUL MRI and spirometry. Ventilation and perfusion MRI was voxel-based quantified: Regional ventilation (RVent, [mL/mL]), flow-volume loop ventilation (FVL, [au]) and perfusion (Q, [mL/min/100 mL]). Whole lung defect maps (VDP, QDP [%]), V/Q ratios (%) based on RVent, FVL and Q were generated. Median MRI parameters were compared with controls, spirometry and perioperative data (Bonferroni correction P<.0045 considered significant).

results84 participants (42 transplant recipients and 42 healthy participants) were evaluated at median 16 days post-transplantation. In lung transplant recipients RVent, FVL and Q did not differ from controls (all P > 0.01). Transplant recipients demonstrated increased RVent VDP (10% vs 3.7%, P < 0.001), VDP

conclusionFree-breathing phase-resolved functional lung MRI-derived parameters revealed increased regional ventilation and perfusion heterogeneity in stable lung transplant recipients two weeks post-transplantation and correlated with spirometry and prolonged cold ischemic times of allografts.

Indexed as

Lung transplantationPhase-resolved functional lung (PREFUL) MRIPulmonary function testingQuantified ventilation–perfusionRegional ventilation-perfusion

Identifiers

PMID42758238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.