Radiomics-based prediction of pituitary adenoma consistency: a systematic review and meta-analysis.

purposePituitary adenoma consistency significantly influences surgical strategy and outcomes, yet it cannot be reliably predicted using conventional imaging. By converting images into quantitative data, radiomics can identify imaging patterns that may not be distinguishable by standard visual interpretation. This study aims to evaluate the diagnostic performance of radiomics-based MRI models for predicting pituitary adenoma consistency, to determine its potential for presurgical planning. MATERIALS AND

methodsA systematic search of PubMed, EMBASE, and Scopus was performed on 12/03/2025 following PRISMA-DTA guidelines and a pre-registered protocol (PROSPERO/CRD420251246028). Eligible studies applied radiomics and machine learning/deep learning to predict pituitary adenoma consistency. We performed random-effects meta-analyses to evaluate the area under the receiver operating characteristic (ROC) curve (AUC). A hierarchical summary ROC (HSROC) model estimated sensitivity and specificity. Risk of bias and study quality were assessed with QUADAS-2 and METRICS.

resultsFourteen studies were included. The pooled discriminative performance was good (AUC = 0.86,95% C.I. [0.76;0.92], I

conclusionsRadiomics-based MRI models demonstrate good diagnostic performance for predicting pituitary adenoma consistency and may support presurgical assessment and planning. However, substantial heterogeneity, evidence of small-study effects, and limited external validation warrant cautious interpretation of the pooled estimates and currently restrict clinical generalizability. Future studies should prioritize multicenter external validation and standardized radiomics workflows.