Evidence map›Paper›PMID 42758235›Full record

ArticleSurgical and radiologic anatomy : SRA2026

Central corneal endothelial morphometry in emmetropic adults aged 20-40 years examined in Valencia, Spain: a retrospective cross-sectional analysis.

Juan A Sanchis-Gimeno, Josepha Hernandez-Nilo, Jessica Paola Loaiza-Giraldo, Nikolaos Lazaridis, George Triantafyllou, Maria Piagkou, Juan José Valenzuela-Fuenzalida

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Article in Surgical and radiologic anatomy : SRA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Juan A Sanchis-GimenoGIAVAL Research Group, Department of Anatomy and Human Embryology, Faculty of Medicine, University of Valencia, 46001, Valencia, Spain. juan.sanchis@uv.es.ORCID https://orcid.org/0000-0002-2599-8474
Josepha Hernandez-NiloDepartamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile.
Jessica Paola Loaiza-GiraldoFacultad de Ciencias de la Salud, Universidad Central del Valle del Cauca (UCEVA), Tuluá, Colombia.
Nikolaos LazaridisAnatomy and Surgical Anatomy Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.
George TriantafyllouDepartment of Anatomy, Faculty of Health Sciences, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Maria PiagkouDepartment of Anatomy, Faculty of Health Sciences, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Juan José Valenzuela-FuenzalidaDepartamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide a descriptive anatomical baseline for central corneal endothelial morphometry and examine cross-sectional associations with recorded sex and age in emmetropic adults examined in Valencia, Spain.

methodsThis retrospective cross-sectional secondary analysis included 202 de-identified records from adults aged 20-40 years. The historical research program operated from 2002 to 2012; exact participant-level examination dates were unavailable. Emmetropia required a spherical equivalent from -0.50 to +0.50 D, manifest sphere and cylinder within ±0.50 D, and best-corrected visual acuity of 20/20 or better. We obtained endothelial cell density (ECD), coefficient of variation of cell area (CV), percentage of hexagonal cells (%HEX), and mean cell area (MCA) using Topcon SP-2000P non-contact specular microscopy. We used Welch tests, Hedges' g, and false-discovery-rate correction for sex comparisons; age-adjusted models used HC3 robust standard errors with diagnostic and sensitivity analyses.

resultsThe sample comprised 106 men and 96 women. Overall values were ECD 2908.1 ± 277.5 cells/mm

conclusionThese device- and sample-specific data provide an anatomical comparator for future studies but are not formal clinical reference intervals or surgical thresholds.

Indexed as

EmmetropiaEndothelium, CornealAdultCell CountCross-Sectional StudiesFemaleHumansMaleRetrospective StudiesSpainYoung AdultCorneal endotheliumCross-sectional studyEmmetropiaEndothelial cell densityMean cell areaNon-contact specular microscopy

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.