Evidence map›Paper›PMID 42758006›Full record

ArticleJournal of human immunity2026

Skin biopsy in adult-onset Still's disease: A specific, rapid, and widely available diagnostic test.

Derrick H Y Chong, Caroline Spaner, Ibrahim Elsharawi, Mark Trinder, Haya Al Bitar, Mariam Goubran, Amelia Perrotta, Rachael Horner, Dilys Chen, Jennifer Corpuz and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Derrick H Y ChongDepartment of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0002-2721-5306
Caroline SpanerDivision of Hematology, University of Toronto, Toronto, Canada.ORCID 0000-0003-1446-9582
Ibrahim ElsharawiDepartment of Pathology, Dalhousie University, Halifax, Canada.ORCID 0000-0003-2059-6895
Mark TrinderDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.ORCID 0000-0001-8447-2897
Haya Al BitarFaculty of Medicine, Dalhousie University, Halifax, Canada.ORCID 0009-0002-5930-1388
Mariam GoubranDivision of Hematology, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-9181-379X
Amelia PerrottaDivision of Dermatology, Dalhousie University, Halifax, Canada.ORCID 0009-0000-2930-4065
Rachael HornerFaculty of Medicine, Dalhousie University, Halifax, Canada.ORCID 0009-0002-9140-765X
Dilys ChenDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.ORCID 0009-0002-7603-1420
Jennifer CorpuzDivision of Rheumatology, University of British Columbia, Vancouver, Canada.ORCID 0009-0001-9140-5497
Kun HuangDivision of Rheumatology, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-0242-6959
Trudy TaylorDivision of Rheumatology, Dalhousie University, Halifax, Canada.ORCID 0009-0008-5751-8149
Ian Marie LanoDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.ORCID 0009-0006-3025-1267
Kerri PurdyDivision of Dermatology, Dalhousie University, Halifax, Canada.ORCID 0009-0000-8484-956X
Jan P DutzDivision of Dermatology & Skin Science, University of British Columbia, Vancouver, Canada.ORCID 0000-0003-3035-0522
Sylvia PasternakDepartment of Pathology, Dalhousie University, Halifax, Canada.ORCID 0000-0002-9636-2588
Richard I CrawfordDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-8669-1898
Luke Y C ChenDivision of Hematology, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-9551-2951

Funding

Nova Scotia Health Research & Innovation HubVGH and UBC Hospital Foundation
6 · The paper itself

Abstract

Adult-onset Still's disease (AOSD) is a diagnostic challenge, as its features overlap with many inflammatory syndromes and no single finding is diagnostic. Skin biopsies showing dyskeratotic keratinocytes (DKs) in the superficial epidermis, including the horny layer, are thought to be highly specific for AOSD but are not included in current diagnostic or classification criteria. We conducted a retrospective clinicopathological study of 16 adults with confirmed AOSD and skin biopsies from a Canadian rare diseases program, and developed a differential diagnosis for superficial DKs using expert consensus and literature review. Clinical morphology varied, but histopathology was similar: 12 of 16 patients had DKs or necrotic keratinocytes in the upper epidermis. Superficial DKs have been reported in conditions distinct from AOSD, but not in its major mimics. Skin biopsy is low-cost, minimally invasive, and widely available and should be performed early in suspected AOSD; superficial DKs should be added to future diagnostic and classification criteria.

Identifiers

PMID42758006
PMCPMC13587882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.