Observational studyBiomedica : revista del Instituto Nacional de Salud2026
Virological failure in HIV-naïve patients with antiretroviral therapy: A perspective from pharmacological variables
Observational study in Biomedica : revista del Instituto Nacional de Salud, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Introduction: Highly active antiretroviral therapy has been shown to improve long-term survival in patients with HIV. However, a considerable proportion of patients experience virologic failure during treatment. Objective: To determine the relationship between polypharmacy, treatment changes, nonadherence, and failure to claim medication, and virologic failure in HIV patients undergoing antiretroviral therapy. Materials and methods: Cross-sectional observational study with multivariate analysis in people with HIV undergoing antiretroviral treatment at a Colombian health institution between 2007-2022, in a census of 4441 patients, where a multiple binary logistic regression was performed with explanatory factors and crude and adjusted OR, confidence intervals and p were calculated. Results: The proportion of virologic failure was 28.1%. The adjusted model demonstrated that polypharmacy, treatment changes, non-adherence, and failure to claim medication were significantly associated with virologic failure. Conclusion: Polypharmacy, treatment changes, non-adherence, and failure to claim medication explain virologic failure in HIV patients undergoing ART.
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