ArticleCell proliferation2026
Derivation of Mouse Dome-Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts.
Minli Liu, Shaofang Ren, Xinyu Xia, Guanlin Lu, Haojie Yang, Yi Zheng, Jiexiang Zhao, Xiao-Yang Zhao, Mei Wang
Abstract read
In one paragraphArticle in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Minli LiuState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0009-5872-374X Shaofang RenState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Xinyu XiaState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Guanlin LuState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Haojie YangState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Yi ZhengState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Jiexiang ZhaoKey Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.ORCID https://orcid.org/0000-0001-7429-5153 Xiao-Yang ZhaoState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-2544-8293 Mei WangState Key Laboratory of Multi-Organ Injury Prevention and Treatment, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-4390-2018 Funding
Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders 2023B1212120004Guangdong Major Project of Basic Research 2025B0303000014Guangzhou Key Research and Development Program 2024B03J0991National Key Research and Development Program of China 2022YFA0806303National Key Research and Development Program of China 2022YFA1106200National Key Research and Development Program of China 2024YFA1802602the National Natural Science Foundation of China 32370911the National Natural Science Foundation of China 32571016the National Natural Science Foundation of China 82530051the National Natural Science Foundation of China U22A20278
6 · The paper itselfAbstract
Trophoblast stem cells (TSCs) have emerged as a valuable model for investigating placentation and related disorders. Despite their ability to be maintained over multiple passages without losing stemness, conventional TSCs are characterised by notorious heterogeneity and a spontaneous differentiation tendency. In this study, we established a type of mouse TSCs with dome-shaped colonies (dTSCs). The dTSCs expressed canonical markers of conventional TSCs and exhibited relatively low levels of heterogeneity and spontaneous differentiation when cultured in conventional trophoblast stem cell medium. Additionally, dTSCs retained robust potential to differentiate into all trophoblast lineages in vitro, as well as the capacity to contribute to placental development in vivo. Furthermore, the functions of Foxo4 and Slc16a3 (MCT4) could be effectively explored in trophoblast development by using our established dTSCs. Collectively, our findings establish a type of high-quality TSCs and define dTSCs as a promising and refined model for investigating trophoblast development.
Indexed as
differentiationheterogeneitymouseplacentatrophoblasttrophoblast stem cells
Identifiers
PMID42757427
PMCPMC13586697
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