ReviewCureus2026
Modified Root Canal Sealers: A Comprehensive Review of Bioactive Enhancements, Antimicrobial Strategies, and Physicochemical Performance.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root canal sealers are essential for achieving a three-dimensional seal of the root canal system, thereby preventing reinfection and facilitating periapical healing. Despite decades of material development, no available sealer satisfies every property expected of an ideal material. This review examines the rationale for modifying conventional sealers, focusing on recurring shortcomings including solubility, cytotoxicity, dimensional instability, and limited bioactivity. Recent work has concentrated on calcium silicate-based and bioceramic chemistries and on the incorporation of nanoparticles, bioactive glass, quaternary ammonium compounds, chitosan, and metal oxides to improve antimicrobial activity, physicochemical stability, and biological function. Experimental modifications generally enhanced antimicrobial activity, ion release, remineralization potential, or biological performance. However, their effects on flow, solubility, dimensional stability, cytocompatibility, and retreatability were formulation- and concentration-dependent, and clinical evidence remains limited. Persistent challenges, particularly retreatability and the shortage of long-term clinical validation, continue to justify further research toward optimized multifunctional endodontic sealers.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.