Evidence map›Paper›PMID 42757350›Full record

ArticleEvidence-based toxicology2026

AI-assisted, human-in-the-loop pipeline for converting historical documents into structured database: a feasibility study of environmental application in Michigan.

Qiong Zhang, Trueman Wu, Yousuf Hussain, Brendan F O'Leary, Carol J Miller, Mei Lu

Abstract read
In one paragraph

Article in Evidence-based toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiong ZhangDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.ORCID 0000-0003-3067-6733
Trueman WuDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.ORCID 0009-0000-8237-0862
Yousuf HussainDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Brendan F O'LearyCenter for Leadership in Environmental Awareness and Research, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-0301-1771
Carol J MillerCenter for Leadership in Environmental Awareness and Research, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-4743-5832
Mei LuDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.ORCID 0000-0002-3313-6428

Funding

Research Experience & Training Coordination CoreP42ES030991 · NIEHS · WAYNE STATE UNIVERSITY · PI Glen Ray Hood · 2022 to 2026
$13.9M
NIEHS NIH HHS P42 ES030991
6 · The paper itself

Abstract

Most states have environmental guidelines or legislation that require any known site of subsurface contamination to undergo a baseline environmental assessment to document contaminant types, concentrations, and subsurface characterization (soil types, groundwater levels, etc.). The resulting publicly available documents are essential in understanding past contamination sources and the potential for future transport or exposure from these sites. Most states have an overwhelming archive of such documents that remain in only paper format, while newer documents are often available digitally. The older documents are very hard to evaluate and use in an efficient manner. Chemical data embedded in the documents were generated by multiple laboratories in varying formats, making them difficult to integrate and use for data analysis and reporting. There is an unmet need to systematically and efficiently extract the chemical data and ensure that the data are both human-readable and machine-readable and meet the principles of FAIR (Findable, Accessible, Interoperable, and Reusable). This study aimed to evaluate the feasibility of an AI-assisted, human-in-the-loop pipeline for extracting, reconstructing, harmonizing, and standardizing tabular chemical data from legacy environmental documents under real-world conditions. This study developed CLEAR-Extract, a scalable, flexible, and modular pipeline integrating optical character recognition, AI-assisted table reconstruction, and structured human quality assurance. Two pipeline configurations-a single-AI configuration emphasizing flexibility and a dual-AI configuration emphasizing efficiency and stability-were applied sequentially to historical brownfield documents from Michigan. Feasibility was assessed at the address level based on successful reconstruction of qualifying chemical tables, correct exclusion of non-qualifying documents, identification of true processing failures, and the degree of required human intervention. Across 99 candidate addresses, the pipeline successfully processed 98% of sites by either reconstructing qualifying chemical concentration tables or correctly excluding documents lacking relevant data. Only two addresses were classified as true failures due to severe document quality limitations. The resulting harmonized database captured volatile organic compound measurements spanning multiple decades and heterogeneous reporting formats, standardized into a common schema suitable for downstream environmental health analysis. This paper demonstrated that CLEAR-Extract, an AI-assisted, human-in-the-loop pipeline, could achieve high reconstruction success from heterogeneous legacy environmental documents. The approach also demonstrated a scalable and transferable framework for converting unstructured historical documents into a FAIR-aligned, analyzable database for environmental health research and regulatory decision-making.

Indexed as

AI-assisted NLP pipelinebrownfieldenvironmental report digitizationFAIR

Identifiers

PMID42757350
PMCPMC13585084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.