ArticleInternational journal of clinical pediatric dentistry2026
Salivary Lactate Dehydrogenase and Matrix Metalloproteinase-8 as Predictive Biomarkers in Early Childhood Caries: A Cross-sectional Study.
Article in International journal of clinical pediatric dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Early childhood caries (ECC) remains a prevalent and aggressive dental disease in preschool children, often progressing rapidly if not detected early. Traditional diagnostic methods are limited to visual and radiographic findings, which may identify lesions only after substantial demineralization. Salivary biomarkers such as lactate dehydrogenase (LDH) and matrix metalloproteinase-8 (MMP-8) have emerged as promising noninvasive indicators of early pathological changes in the oral environment. Aim: To evaluate salivary LDH and MMP-8 levels in preschool children with and without ECC and to assess their potential as predictive biomarkers. Materials and methods: A cross-sectional study was conducted on 80 children aged 3-6 years. Participants were divided into two groups: group I (caries-free, Results: Mean salivary LDH levels were significantly higher in the ECC group (365.2 ± 42.8 U/L) compared to the caries-free group (228.5 ± 38.6 U/L, Conclusion: Elevated salivary LDH and MMP-8 levels are associated with ECC, suggesting their potential role as predictive biomarkers for early diagnosis and preventive interventions. How to cite this article: Kommalapati V, Soorneedi N, Supraja AN,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.