ReviewTanaffos2025
Global Research Trends on Tuberculosis: A Bibliometric and Visualized Study of Clinical Trials.
Review in Tanaffos, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis stands as a prominent global infectious disease, ranking among the leading causes of mortality. Its complex pathogenesis and significant resistance to existing treatments have made the eradication of this disease challenging. Over the 20th century and into the present, numerous endeavors have been undertaken to comprehensively understand various aspects of this disease and find a proper solution to this challenge. This scientometric study employs the content analysis method to provide an overview of existing clinical trials in the tuberculosis field. We conducted a comprehensive review using the World Health Organization Clinical Trials Registry database, covering studies registered between 1998 and 2021. A total of 1,590 tuberculosis-related clinical trials were registered across global clinical trial registries through the end of 2021. Significant joint initiatives were observed, notably between South Africa and India (53 studies), South Africa and Peru (47 studies), and South Africa and Uganda (40 studies). There was a predominant focus on Human Immunodeficiency Virus (HIV) diseases (14.15% of trials). Pulmonary tuberculosis with 316 (19.87%) trials and multidrug-resistant tuberculosis with 92 (5.76%) trials were the most evaluated topics. Drug-based interventions led with 942 studies (58.25), and Isoniazid was evaluated in 261 trials (16.42%). Conclusion: Scientometric analyses provide valuable insights into research trends across diverse fields, helping researchers identify knowledge gaps and guide future investigations. The steadily increasing annual registration of clinical trials, together with persistent gaps in our understanding of tuberculosis pathogenesis, prevention, and treatment, and the substantial global burden of disease, underscores the need for continued research in this field.
Indexed as
Identifiers
42757300PMC13585148What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.