ArticleRSC advances2026
Improved nucleic acid sensing, exemplified using pure target DNA sequences, by MO capture probes compared to DNA capture probes, as revealed from PO
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Detection of gene mutations is central to molecular diagnostics. The conventional detection methods that employ DNA capture probes are widely used, yet they may suffer from non-specific signals, difficulties in single nucleobase mismatch discrimination, and nuclease-induced degradation of the DNA capture probe. Herein, a strategy for detection of nucleic acid sequences using the nuclease-resistant morpholino oligonucleotide (MO) capture probe is reported. Since, spherical NPs offer increased surface area, thus increasing the total number of capture probe available for target recognition, MO probes were immobilized onto spherical NPs. Time-of-flight secondary ion mass spectrometry (TOF-SIMS), a sensitive surface analysis method, was employed to assess the status of target binding. Target binding was confirmed by recognizing the differences in chemical structures of MO and DNA,
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