ArticleACS omega2026
Flexible Catechol-Conjugated Chitosan/Gelatin Bilayer Patches for Topical Hemostasis in Laparoscopic Surgery.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, mussel-inspired catechol-conjugated chitosan (CHI-C)-based topical hemostats have been developed to arrest intraoperative bleeding in patients with coagulopathy through interactions between CHI-C and blood proteins. Pseudo-active blood coagulation, defined as material-assisted clot formation through CHI-C-blood protein complexation without exogenous coagulation proteins, is achieved using CHI-C/gelatin (CHI-C/Geln) bilayer structures. However, these bilayer hemostats still have limitations in laparoscopic surgical settings owing to their stiffness, which can impair trocar deliverability. In this study, we optimized CHI-C/Geln bilayer patches for laparoscopic surgical application by controlling patch thickness through compression. We prepared three types of CHI-C/Geln patches with thicknesses of 1, 3, and 5 mm to compare their tissue adhesiveness, mechanical properties, trocar deliverability, and hemostatic capability. The CHI-C/Geln patches with thicknesses of 1 and 3 mm could pass through 10-12 mm trocars without fragmentation during rolling or repeated folding. In addition, the 3-mm-thick CHI-C/Geln patches exhibited effective tissue adhesiveness, bursting pressure, and hemostatic ability. Thus, these flexible adhesive patches could serve as topical hemostats that function effectively in laparoscopic surgery.
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Registered trials
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