Evidence map›Paper›PMID 42757153›Full record

ReviewACS omega2026

Carbamate-Bearing Carbohydrates: Natural Occurrence, Pharmacological Relevance, and Chemical Synthesis.

Vincent Maltais-Bourgeois, André Pichette, Joanne Plourde, Laéla Lephore, Jean Legault, Jérôme Alsarraf

Abstract readReview
In one paragraph

Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vincent Maltais-BourgeoisCentre de Recherche sur la Boréalie (CREB), Laboratoire d'analyse et de Séparation des Essences Végétales (LASEVE), Université du Québec à Chicoutimi, 555 Boulevard de l'université, Chicoutimi G7H 2B1, Quebec, Canada.
André PichetteCentre de Recherche sur la Boréalie (CREB), Laboratoire d'analyse et de Séparation des Essences Végétales (LASEVE), Université du Québec à Chicoutimi, 555 Boulevard de l'université, Chicoutimi G7H 2B1, Quebec, Canada.
Joanne PlourdeCentre de Recherche sur la Boréalie (CREB), Laboratoire d'analyse et de Séparation des Essences Végétales (LASEVE), Université du Québec à Chicoutimi, 555 Boulevard de l'université, Chicoutimi G7H 2B1, Quebec, Canada.
Laéla LephoreCentre de Recherche sur la Boréalie (CREB), Laboratoire d'analyse et de Séparation des Essences Végétales (LASEVE), Université du Québec à Chicoutimi, 555 Boulevard de l'université, Chicoutimi G7H 2B1, Quebec, Canada.
Jean LegaultCentre de Recherche sur la Boréalie (CREB), Laboratoire d'analyse et de Séparation des Essences Végétales (LASEVE), Université du Québec à Chicoutimi, 555 Boulevard de l'université, Chicoutimi G7H 2B1, Quebec, Canada.
Jérôme AlsarrafCentre de Recherche sur la Boréalie (CREB), Laboratoire d'analyse et de Séparation des Essences Végétales (LASEVE), Université du Québec à Chicoutimi, 555 Boulevard de l'université, Chicoutimi G7H 2B1, Quebec, Canada.ORCID https://orcid.org/0000-0003-4641-2599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbamoylation is a relatively rare but relevant modification in natural carbohydrates, promoting structural diversity. Numerous families of natural glycosides, including aminocoumarins, glycopeptides, or macrolides, contain these carbamoylated carbohydrates. These natural products display a broad spectrum of pharmacological properties. In several cases, the carbamate-bearing carbohydrate contributes to these bioactivities. The synthesis of carbamate-bearing carbohydrates presents important challenges, and has been conventionally achieved through multistep sequences and the use of toxic and unstable reagents. Recent advances in catalytic site-selective carbamoylation enabled more efficient and safer syntheses of these unique carbohydrates. These advancements facilitate the study of carbamate-bearing carbohydrates, potentially accelerating the discovery of novel therapeutic agents.

Identifiers

PMID42757153
PMCPMC13584161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.