Evidence map›Paper›PMID 42757150›Full record

ArticleACS omega2026

Structural Characterization of Calcium-Dependent Calmodulin-Calmidazolium Binding Using Capillary Vibrating Sharp-Edge Spray Ionization-Based Native Mass Spectrometry and In-Droplet Hydrogen-Deuterium Exchange Mass Spectrometry.

Sohag Ahmed, Axel Woehrling, Peng Li, Stephen J Valentine, Kevin C Courtney

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sohag AhmedDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Axel WoehrlingDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0009-0000-6900-944X
Peng LiDepartment of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, Pennsylvania 18015, United States.
Stephen J ValentineDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0003-4360-2928
Kevin C CourtneyDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0003-1315-4917

Funding

Developing an integrated system for detailing the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotidesR01GM153899 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Peng Li, Aaron Reigh Robart · 2024 to 2026
$1.5M
Regulation of SNARE-mediated autophagosome-lysosome fusion by accessory proteinsR35GM160081 · NIGMS · WEST VIRGINIA UNIVERSITY · PI COURTNEY, KEVIN C · 2025 to 2025
$407k
NIGMS NIH HHS R01 GM153899NIGMS NIH HHS R35 GM160081
6 · The paper itself

Abstract

Capillary vibrating sharp-edge spray ionization (cVSSI)-based native mass spectrometry (nMS) and in-droplet hydrogen-deuterium exchange (HDX-MS) were used to evaluate calcium-dependent interactions between calmodulin and calmidazolium (CDZ). cVSSI was found to produce a narrow charge-state distribution (CSD) with low average charge states, indicating that this method preserved native-like states. cVSSI was also able to resolve stepwise Ca

Identifiers

PMID42757150
PMCPMC13584159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.