Evidence map›Paper›PMID 42757133›Full record

ArticleBioactive materials2027

3D-printed PCL scaffold coated with chitosan-hyaluronic acid hydrogel loaded with NGF-overexpressing UiPSC-derived neural crest cells restores erectile function via cavernous nerve regeneration.

Han Cheol Yeo, Hoyoung Bae, Jae-Seok Kim, Jun-Kyu Kang, Jaekwon Seok, Yoo Jung Kim, Ye Ji Han, Ye Been Na, Sun Hee Lee, Junghoon Lee and 5 more

Abstract read
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In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Han Cheol YeoStem Cell and Regenerative Biotechnology Major, School of Advanced Biotechnology, College of Institute of Science and Technology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Institute of Health, Aging & Society, Konkuk University, Seoul, 05029, Republic of Korea.
Hoyoung BaeDepartment of Urology, Seoul National University College of Medicine and Seoul National University Boramae Medical Center, Seoul, 03080, Republic of Korea.
Jae-Seok KimDepartment of Mechanical Engineering, Wonkwang University, Iksan, 54538, Republic of Korea.
Jun-Kyu KangDepartment of Chemical Engineering, Wonkwang University, Iksan, 54538, Republic of Korea.
Jaekwon SeokStem Cell and Regenerative Biotechnology Major, School of Advanced Biotechnology, College of Institute of Science and Technology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Institute of Health, Aging & Society, Konkuk University, Seoul, 05029, Republic of Korea.
Yoo Jung KimStem Cell and Regenerative Biotechnology Major, School of Advanced Biotechnology, College of Institute of Science and Technology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Institute of Health, Aging & Society, Konkuk University, Seoul, 05029, Republic of Korea.
Ye Ji HanStem Cell and Regenerative Biotechnology Major, School of Advanced Biotechnology, College of Institute of Science and Technology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Institute of Health, Aging & Society, Konkuk University, Seoul, 05029, Republic of Korea.
Ye Been NaDepartment of Urology, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Sun Hee LeeDepartment of Urology, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Junghoon LeeDepartment of Urology, Seoul National University College of Medicine and Seoul National University Boramae Medical Center, Seoul, 03080, Republic of Korea.
So-Jung GwakDepartment of Chemical Engineering, Wonkwang University, Iksan, 54538, Republic of Korea.
Seung-Jae LeeDepartment of Mechanical Engineering, Wonkwang University, Iksan, 54538, Republic of Korea.
Ssang-Goo ChoStem Cell and Regenerative Biotechnology Major, School of Advanced Biotechnology, College of Institute of Science and Technology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Institute of Health, Aging & Society, Konkuk University, Seoul, 05029, Republic of Korea.
Soo Woong KimDepartment of Urology, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, 03080, Republic of Korea.
Min Chul ChoDepartment of Urology, Seoul National University College of Medicine and Seoul National University Boramae Medical Center, Seoul, 03080, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated whether erectile function could be restored by promoting cavernous nerve (CN) regeneration via perineural administration of nerve-growth-factor (NGF)-overexpressing neural-crest-cells (NCCs) within a 3D-printed cytocompatible scaffold in a CN-injured rat model. We generated induced-pluripotent-stem-cells (iPSCs) from urine-derived stem-cells (USCs), overexpressed NGF, and differentiated them into NCCs. Additionally, a polycaprolactone (PCL) scaffold was fabricated via extrusion 3D-printing and coated with a thermosensitive chitosan/hyaluronic acid (HA)/β-glycerophosphate hydrogel. The NGF-NCCs were loaded onto the scaffold, with

Indexed as

3-Dimensional printingErectile dysfunctionHyaluronic acid hydrogelNerve growth factorNeural crest cell

Identifiers

PMID42757133
PMCPMC13584137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.