Evidence map›Paper›PMID 42757130›Full record

ReviewFrontiers in immunology2026

The transformative impact of ultra-rapid nanopore sequencing in precision medicine.

Sarah Grasedieck, Brendan J Keating, Stephen Yip, James Lan, Karen R Sherwood, Paul A Keown

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah GrasedieckDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Brendan J KeatingDepartment of Surgery, University of Pennsylvania, Philadelphia, PA, United States.
Stephen YipMolecular Oncology, British Columbia (BC) Cancer, Vancouver, BC, Canada.
James LanDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Karen R SherwoodDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Paul A KeownDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.

Funding

Project 2U19AI191396 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Brendan James Keating · 2025 to 2026
$8.5M
NIAID NIH HHS U19 AI191396
6 · The paper itself

Abstract

Nanopore sequencing has emerged as a transformative technology, offering unprecedented speed, ultra-long reads, and portability at a comparatively low cost. These attributes are fundamentally reshaping clinical diagnostics and personalized medicine. This review synthesizes the technological advancements driving nanopore sequencing and elucidates its pivotal applications in time-sensitive areas such as HLA matching in transplantation, infectious disease management, pharmacogenomics, and oncology. Nanopore sequencing also enables comprehensive characterization of immune-related genomic variation including HLA, KIR, LILR, Fc receptor loci, immune regulatory variants and epigenetic features. We explore the profound impact of real-time genomics on patient care, emphasizing the potential for point-of-care testing, the acceleration of clinical decision support, and the realization of precision medicine.

Indexed as

Nanopore SequencingPrecision MedicineGenomicsHumansPharmacogeneticsadaptive samplinggenetic testinggenome medicineinfectious disease managementpharmacogenomic (PGx) testingpublic healthrare disease diagnosticstransplantation

Identifiers

PMID42757130
PMCPMC13584189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.