Evidence map›Paper›PMID 42757099›Full record

ArticleEuropean urology open science2026

Ice Water Test Unmasks Detrusor Overactivity in Apparently Normal Conventional Cystometry.

Lara Stächele, Helen Sadri, Collene E Anderson, Veronika Birkhäuser, Oliver Gross, Fabienne Lehner, Lorenz Leitner, Martina D Liechti, Ulrich Mehnert, Thomas M Kessler

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Article in European urology open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Lara StächeleDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Helen SadriDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Collene E AndersonDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Veronika BirkhäuserDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Oliver GrossDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Fabienne LehnerDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Lorenz LeitnerDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Martina D LiechtiDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Ulrich MehnertDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Thomas M KesslerDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: To evaluate the diagnostic value of the ice water test (IWT) in unmasking detrusor overactivity (DO) in patients with lower urinary tract symptoms (LUTS) who do not exhibit DO during conventional filling cystometry and to characterize this specific patient population. Design setting and participants: In this observational cohort study, from April 2021 to December 2023, patients with LUTS but no DO in same-session repeat conventional filling cystometry were additionally evaluated using the IWT. All participants underwent standardized urodynamic investigations following International Continence Society guidelines. Outcome measurements and statistical analysis: The primary outcome was the presence of DO during the IWT. Demographic and clinical factors associated with DO were analyzed using mixed-effects logistic regression models. Results and limitations: In 529 UDIs of 451 patients (63 patients had more than one urodynamic investigation (UDI)) without DO in conventional filling cystometry, the IWT revealed DO in 51% (229/451). Detection was more frequent in patients with an underlying neurological disorder (53% vs 34%, Conclusions: In patients with LUTS but no DO on conventional filling cystometry, the IWT might reveal DO in approximately half of the cases. This underscores the diagnostic value of the IWT in both patients with neurological and nonneurological conditions and leads to a better understanding of LUTS-causing pathophysiology.

Indexed as

CystometryDetrusor overactivityIce water testLower urinary tract symptomsUrodynamics

Identifiers

PMID42757099
PMCPMC13584125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.