ArticleInternational journal of clinical pediatric dentistry2026
A Randomized Controlled Trial to Evaluate and Compare the Effectiveness of Two Fluoride Varnishes Containing Casein Phosphopeptide-Amorphous Calcium Phosphate and Xylitol with Brushing Twice Daily Regimen in Preventing Dental Caries among 3-6-year-old Preschool Children.
Article in International journal of clinical pediatric dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Early childhood caries (ECC) is a rapidly progressing condition in preschool children. While fluoride is the gold standard for caries prevention, adjuncts like casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol may enhance its effectiveness in preventing dental caries. Aim: To compare the effectiveness of fluoride varnishes containing CPP-ACP and another xylitol vs brushing with fluoridated toothpaste in preventing caries among preschool children. Materials and methods: A three-arm randomized controlled trial was conducted among 60 children aged 3-6 years. Group I received Enamelast™ (fluoride + xylitol) varnish with brushing, group II received MI Varnish™ (fluoride + CPP-ACP) with brushing, and group III followed brushing with fluoridated toothpaste only. Varnishes were applied at baseline and 6 months. The caries increment [decayed, missing, and filled surfaces in primary teeth/permanent teeth (dmfs/DMFS)] was evaluated at baseline, 6 months, and 12 months. Results: At 12 months, both varnish groups showed significantly lower caries increments than brushing alone ( Conclusion: Both varnishes were superior to brushing alone in preventing ECC, with MI Varnish™ demonstrating the slowest progression. Fluoride varnishes, particularly when combined with remineralizing agents, provide effective adjunctive strategies for caries prevention in preschool children. Clinical significance: Fluoride varnishes with CPP-ACP or xylitol were more effective than brushing alone in reducing ECC. Though MI Varnish™ (CPP-ACP) showed the slowest progression, the difference between varnishes was not significant. How to cite this article: Salam J, Pandit IK, Gugnani N,
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