Evidence map›Paper›PMID 42757004›Full record

ArticleiScience2026

Hyun S Kim, Jonathon T Intravaia, Trevon Graham, Sangamesh G Kumbar, Syam P Nukavarapu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyun S KimDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Jonathon T IntravaiaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Trevon GrahamDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Sangamesh G KumbarDepartment of Growth and Development, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Syam P NukavarapuDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.

Funding

Biodegradable Matrices for Bone HealingR01EB020640 · NIBIB · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA, YU, XIAOJUN · 2017 to 2020
$1.6M
Biodegradable Matrices with Structural and Physical Cues for Interface EngineeringR01EB030060 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NUKAVARAPU, SYAM · 2020 to 2024
$1.4M
NIBIB NIH HHS R01 EB020640NIBIB NIH HHS R01 EB030060
6 · The paper itself

Abstract

Scaffolds that simultaneously provide bioactivity, osteoinduction, and structural stability are essential yet remain elusive in bone tissue engineering. Here, we developed degradable amorphous silica fiber scaffolds that actively support biomineral nucleation and growth while maintaining long-term stability. The scaffolds degraded linearly over 40 weeks, and biomineralization enhanced compressive modulus by more than 100%.

Indexed as

amorphous silicabonenew biomaterial platformtissue engineering

Identifiers

PMID42757004
PMCPMC13584059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.