ArticleInternational journal of nanomedicine2026
Anion-Dependent Layered Double Hydroxide-Reinforced Gelatin Methacryloyl Hydrogels for Osteoimmunomodulation and Bone Regeneration.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Persistent inflammation and insufficient osteogenesis jointly limit the repair of critical-sized bone defects. This study aimed to develop an anion-programmable osteoimmunomodulatory hydrogel based on magnesium-aluminum layered double hydroxide (LDH) nanoparticles and gelatin methacryloyl (GelMA), determine whether LDH interlayer anions regulate immune-skeletal crosstalk, and evaluate whether this strategy enhances repair of critical-sized calvarial bone defects. Methods: Chloride- and nitrate-intercalated MgAl-LDH nanoparticles (LDH-Cl Results: Thoroughly washed low- and high-magnification confocal images demonstrated FITC-LDH association/internalization in macrophages and BMSCs without apparent cytotoxicity. In lipopolysaccharide-activated macrophages, LDH nanoparticles reduced TNF-α and IL-1β expression while increasing TGF-β and IL-10 expression, with LDH-NO Conclusion: Interlayer anion engineering of LDH nanoparticles, particularly nitrate intercalation, provides a strategy for constructing immunoactive GelMA-based hydrogels that coordinate inflammation resolution and osteogenic repair in critical-sized bone defects.
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