ArticleFrontiers in veterinary science2026
Increased detectability of Apolipoprotein E (ApoE) in cerebrospinal fluid samples of dogs with peracute and acute central nervous system lesions.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Apolipoprotein E (ApoE), secreted by astrocytes and microglia after neuronal injury, is involved in neuronal regeneration and modulation of inflammatory processes. Inverse associations between ApoE and the proinflammatory mediator C-reactive protein (CRP) are described in mice, but knowledge in dogs is limited. Methods: This study investigated ApoE levels in cerebrospinal fluid (CSF) from 141 dogs with central nervous system (CNS) diseases, including idiopathic epilepsy ( Results: ApoE was detected in 66/151 cases, of which 20 showed quantifiable levels, exclusively in diseased dogs. While dogs with peracute IVDH or high seizure frequency were significantly associated with detected ApoE, MUO cases with multiple lesions only had a trend for measurable ApoE levels. Contrary to our hypothesis, a significant positive correlation between ApoE and CRP in CSF was found, suggesting a potential modulatory role of ApoE in neuroinflammation. Discussion: In conclusion, ApoE may play a role particularly during peracute and acute disease stages, while low CSF ApoE may reflect regenerative processes in affected neuronal tissue.
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