Evidence map›Paper›PMID 42756855›Full record

ReviewNAM journal2026

Cytotoxicity across OECD methods is not a single endpoint: context-dependent roles, variability and implications for decision-making.

Tizia Thoma, Lara Löhr, Philipp Demuth, Nina Hambruch, Franz Oesch, Robert Landsiedel

Abstract readReview
In one paragraph

Review in NAM journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tizia ThomaBASF Metabolome Solutions GmbH, Scientific Support, Berlin, Germany.
Lara LöhrUniversity of Leipzig, Postgraduate Curriculum in Toxicology, Leipzig, Germany.
Philipp DemuthBASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany.
Nina HambruchBASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany.
Franz OeschJohannes Gutenberg University, Mainz, Germany.
Robert LandsiedelBASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxicity and proliferation measurements are widely used in OECD

Indexed as

Assay interpretationCytostasisGIVIMPOECD test guidelines

Identifiers

PMID42756855
PMCPMC13583590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.