Evidence map›Paper›PMID 42756835›Full record

ArticleBrain, behavior, & immunity - health2026

The thymus gland is a target and maintainer of amyotrophic lateral sclerosis pathophysiology.

Julia Pereira Lemos, Daniel Stockholm, Brenda Dinatale, Amanda Silva Chaves, Sonia Pezet, Vinicius Frias Carvalho, Ana Rosa Pérez, Daniella Arêas Mendes-da-Cruz, Wilson Savino, Piera Smeriglio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia Pereira LemosSorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, F-75013, France.
Daniel StockholmPSL Research University, EPHE, Paris, F-75014, France.
Brenda DinataleInstitute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET), Faculty of Medical Sciences, National University of Rosario, Rosario, Argentina.
Amanda Silva ChavesLaboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Sonia PezetSorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, F-75013, France.
Vinicius Frias CarvalhoLaboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Ana Rosa PérezInstitute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET), Faculty of Medical Sciences, National University of Rosario, Rosario, Argentina.
Daniella Arêas Mendes-da-CruzNational Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Wilson SavinoNational Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Piera SmeriglioSorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, F-75013, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective loss of motor neurons in the brain and spinal cord with evidence of local neuroinflammation. Regulatory T cells (Treg) exert neuroprotective effects and correlate with disease progression, but central mechanisms governing Treg development during ALS remain unclear. We investigated the thymic architecture and T cell differentiation in SOD1-G93A (mSOD1) ALS mice at multiple disease stages. Thymocyte and thymic epithelial cells (TEC) subpopulations, as well as stages of Treg differentiation and suppressive capacity, were analyzed by flow cytometry,

Indexed as

Amyotrophic lateral sclerosis (ALS)Immune homeostasisRegulatory T cells (Treg)SOD1-G93A mouse modelThymocyte developmentThymus

Identifiers

PMID42756835
PMCPMC13583610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.