Evidence map›Paper›PMID 42756828›Full record

ArticleACS omega2026

Design and Evaluation of PLGA-Based Hybrid Nanoparticles for Nasal Paclitaxel Delivery: Formulation Optimization, Barrier Transport, and Cytotoxicity Assessment.

Anna Carolina da Silva Sousa, Caroline Mari Ramos Oda, André Luis Branco de Barros, Maria Betânia de Freitas Marques, Chun Yuen Jerry Wong, Hui Xin Ong, Daniela Traini, Elaine Amaral Leite

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna Carolina da Silva SousaDepartment of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID https://orcid.org/0009-0007-5487-1046
Caroline Mari Ramos OdaDepartment of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais 31270-901, Brazil.
André Luis Branco de BarrosDepartment of Clinical and Toxicological Analyses, Faculty of Pharmacy, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID https://orcid.org/0000-0002-7641-6585
Maria Betânia de Freitas MarquesDepartment of Food and Drug, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, Minas Gerais 37130-001, Brazil.ORCID https://orcid.org/0000-0002-0561-2343
Chun Yuen Jerry WongRespiratory Technology, Woolcock Institute of Medical Research, Sydney, New South Wales 2037, Australia.
Hui Xin OngRespiratory Technology, Woolcock Institute of Medical Research, Sydney, New South Wales 2037, Australia.
Daniela TrainiRespiratory Technology, Woolcock Institute of Medical Research, Sydney, New South Wales 2037, Australia.
Elaine Amaral LeiteDepartment of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID https://orcid.org/0000-0001-8812-3811

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paclitaxel (PTX) is a potent antiglioma agent, but its clinical use is limited by poor penetration across the blood-brain barrier (BBB). This study developed and evaluated a nose-to-brain delivery strategy using paclitaxel-loaded hybrid nanoparticles (HNP-PTX) for intranasal administration. A full 2

Identifiers

PMID42756828
PMCPMC13584801

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.