ArticleFrontiers in nutrition2026
Combined effects of resistant dextrin and inulin on the reduction of harmful metabolites during
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/objectives: Aging-related dysbiosis is associated with increased production of harmful gut-derived metabolites. Reducing these metabolites by modulating the gut microbiota is important for maintaining health in older adults. This study aimed to investigate whether a combination of resistant dextrin and inulin suppresses the production of harmful metabolites in the gut microbiota of older adults using Methods: Fecal samples from eight older adults were fermented with resistant dextrin, inulin, their combination, or no saccharides as a control. Potentially harmful metabolites in the fermentation supernatants were assessed by metabolomic analysis. Trimethylamine production was verified by the fecal fermentation with a choline-supplemented medium. Results: The combination group showed a decreasing trend in the production of deoxycholic acid, kynurenine, and trimethylamine compared with the control group. Assessment of trimethylamine production using a choline-supplemented medium revealed that the combination group had a higher proportion of fecal samples with low trimethylamine production (3 of 8 samples) than either prebiotic-alone group. Conclusion: Combining resistant dextrin and inulin could reduce the production of some harmful metabolites by the gut microbiota in older adults.
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