Evidence map›Paper›PMID 42756782›Full record

ArticleAdvances in hematology2026

Hemorrhagic Cystitis in Patients Who Underwent Allogeneic Stem Cell Transplantation (2012-2025): A Single-Center Experience.

Khanh Ba Nguyen, Binh Thi Thanh Vo, Nhung Thi Nguyen, Thanh Ha Nguyen

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Article in Advances in hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Khanh Ba NguyenDepartment of Hematology, Hanoi Medical University, Hanoi 100000, Vietnam, hmu.edu.vn.ORCID https://orcid.org/0009-0003-1698-6361
Binh Thi Thanh VoStem Cell Transplantation Department, National Institute of Hematology and Blood Transfusion, Hanoi 100000, Vietnam.
Nhung Thi NguyenStem Cell Transplantation Department, National Institute of Hematology and Blood Transfusion, Hanoi 100000, Vietnam.
Thanh Ha NguyenDepartment of Hematology, Hanoi Medical University, Hanoi 100000, Vietnam, hmu.edu.vn.ORCID https://orcid.org/0000-0002-4884-0522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hemorrhagic cystitis (HC) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT), especially in cases with haploidentical donors. Our study aimed to determine the incidence and analyze the risk factors associated with HC in patients undergoing allogeneic HSCT. Subjects and Methods: This retrospective, cross-sectional study analyzed data from 343 patients who underwent allogeneic HSCT between January 2012 and June 2025 at our institution. The research variables included clinical characteristics, conditioning regimens, BK virus (BKV) status, and transplant outcomes. Results: The overall incidence of HC was 18.4% (63 out of 343 patients), with severe cases (Grades 3-4) comprising 9.4%. The median onset was 33 days posttransplantation, with a median duration of 40 days. BKV was detected in the urine of 19.9% of the patients, among whom 15.2% exhibited high viral loads. Multivariate Cox regression analysis identified three independent risk factors: malignant disease (hazard ratio [HR] = 4.212; Conclusion: HC is a prevalent complication of allogeneic HSCT, often presenting late and closely associated with malignancies, severe infections, and PTcy protocols. The severity of HC is a crucial determinant of survival outcomes, necessitating proactive preventive strategies and timely interventions to enhance the patient's prognosis.

Indexed as

allogeneic hematopoietic stem cell transplantationBK virushemorrhagic cystitisposttransplant cyclophosphamideprognosis

Identifiers

PMID42756782
PMCPMC13584321

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