ArticleFrontiers in pharmacology2026
Targeting skin aging: anti-senescent potential and key enzyme modulation of
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Skin aging is an inherent biological process linked to chronological aging that can be accelerated by external factors. Cellular senescence and skin enzymes are crucial players in this process and, therefore, relevant preventive and therapeutic targets. In this scenario, aromatic plants and their essential oils have gained attention as promising agents in the management of skin aging. The present study aims to explore the anti-senescent potential of Methods: The chemical characterization of the essential oils was carried out by gas chromatography-mass spectrometry and their effect evaluated on etoposide-induced senescent fibroblasts during the recovery phase. Relevant markers of cellular senescence were analyzed, namely, β-galactosidase activity through a colorimetric assay, nuclear alterations by immunofluorescence, SASP secretion through ELISA, expression levels of cell cycle inhibitors by WB analysis and ultrastructural alterations using transmission electron microscopy. Modulation of key enzyme activity was determined using an Results: The essential oil of Conclusion: These results highlight the potential of
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