Evidence map›Paper›PMID 42756739›Full record

ArticleMolecular genetics and metabolism reports2026

Efficacy of plasma exchange and exchange transfusion in the clinical management of severe hypertriglyceridemia in emergency.

C Stefanutti, G Zeppa, G Perrone, G Labbadia, P Galoppi, V Demarco, E Fornari, A Bordugo, C Santelia, V Mancioppi and 12 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

C StefanuttiDepartment of Molecular Medicine, Extracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Regional Centre for Rare Diseases, Immunohematology and Transfusion Medicine, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
G ZeppaDepartment of Molecular Medicine, Extracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Regional Centre for Rare Diseases, Immunohematology and Transfusion Medicine, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
G PerroneDepartment of Maternal and Child Health and Urological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
G LabbadiaDepartment of Internal Medicine, Anesthesiology and Cardiovascular Clinical Sciences UOC Internal Medicine and Atherosclerosis Prevention, Italy.
P GaloppiDepartment of Maternal and Child Health and Urological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
V DemarcoDepartment of Maternal and Child Health and Urological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
E FornariU.O.C. di Pediatria B, Centro Regionale Specializzato per la Diabetologia Pediatrica, Azienda Ospedaliera Universitaria Integrata, Ospedale della Donna e del Bambino, Piazzale A. Stefani 1, Verona 37126, Italy.
A BordugoCentro Coordinamento Regionale Malattie Rare, Azienda Ospedaliera Friuli Centrale, ASUFC Udine, Italy.
C SanteliaSOC Neonatologia, Azienda Ospedaliera Friuli Centrale, ASUFC Udine, Italy.
V MancioppiU.O.C. di Pediatria B, Centro Regionale Specializzato per la Diabetologia Pediatrica, Azienda Ospedaliera Universitaria Integrata, Ospedale della Donna e del Bambino, Piazzale A. Stefani 1, Verona 37126, Italy.
M G ZentiServizio di Diabetologia, Malattie Metaboliche e Nutrizione Clinica, "Ospedale P. Pederzoli" - Casa di Cura Privata S.p.A, Via Monte Baldo 24, Peschiera del Garda, 37019 Verona, Italy.
M CossuS.C. Nefrologia Dialisi e Trapianto, Azienda Ospedaliera Universitaria - Ospedale SS. Annunziata, Via Enrico De Nicola 39, 01700 Sassari, Italy.
B SovranoDepartment of Molecular Medicine, Extracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Regional Centre for Rare Diseases, Immunohematology and Transfusion Medicine, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
A VivenzioDepartment of Molecular Medicine, Extracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Regional Centre for Rare Diseases, Immunohematology and Transfusion Medicine, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
H CohenThe Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, 5265601, Gray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Israel.
H SoranNIHR/WELLCOME Trust Clinical Research Facility and Department of Endocrinology, Diabetes and Metabolism, Peter Mount Building, Manchester University Hospital NHS Foundation Trust, Oxford Road, M13 9 WL Manchester, United Kingdom.
L PisciottaIRCCS Ospedale Policlinico San Martino, Italy.
C MaffeisU.O.C. di Pediatria B, Centro Regionale Specializzato per la Diabetologia Pediatrica, Azienda Ospedaliera Universitaria Integrata, Ospedale della Donna e del Bambino, Piazzale A. Stefani 1, Verona 37126, Italy.
B BjelakovicDept. of Cardiology, Clinic of Pediatrics, Clinical Centre - Nis, Medical Faculty, University of Nis, Blvd Zorana Djindjica 81, 18000 Nis, Serbia.
K WidhalmMedical University of Vienna, Austrian Academic Institute for Clinical Nutrition, Alserstraße 14/4a, Vienna 1090, Austria.
G RizzoDepartment of Maternal and Child Health and Urological Sciences, Umberto I Hospital, "Sapienza" University of Rome, Viale del Policlinico 155, Rome, 00161, Italy.
MIGHTY MEDIC - Multidisciplinary International Group for Hemapheresis Therapy and Metabolic Disorders Control

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The management involving genetic evaluation and therapy for SHTG of 21 subjects having SHTG either associated with AP or not is discussed within the context of a multinational, clinical case record analysis. Methods: A retrospective case series study of 21 patients with severe hypertriglyceridemia (SHTG) with or without acute pancreatitis (AP) involving recurrent AP cases was performed. The clinical profile, genetic background, and results of treatments using therapeutic plasma exchange (TPE) and/or exchange transfusion (ET) were analyzed among a mixed group of adult patients, children, pregnant females, and one neonate. Results: Patients were symptomatic and were admitted via the ER. Patients who received therapy using TPE or ET had a significant reduction in plasma lipid and lipoprotein levels with improvement in their symptoms. Other treatments, such as TG-lowering agents, can also be used but are less beneficial at this stage in the management of rapidly lowering TG levels. Conclusion: This choice of TPE or ET for 16 patients with clinical signs of acute pancreatitis induced by SHTG was proper. Considering that this is a retrospective study without randomization, the results are more a confirmation of successful use rather than an indication of superiority over standard therapy.

Indexed as

Acute pancreatitis (AP)DyslipidemiaExchange transfusion (ET)Familial chylomicronemia syndrome (FCS)Rare diseaseSevere hypertriglyceridemia (SHTG)Therapeutic plasma exchange (TPE)

Identifiers

PMID42756739
PMCPMC13583583

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