Evidence map›Paper›PMID 42756671›Full record

ReviewMediterranean journal of rheumatology2026

Impaired Bone Physiology in Rheumatoid Arthritis: Can the Wnt Pathway be the Connecting Link Between the Synovium and the Bone?

Michail I Krikelis, Dimitra Moschou, Konstantina Zoupidou, Evangelia Mole, Konstantinos Makris, Simeon Tournis, Sousana Gazi, Vassilios Nikolaou, Clio Mavragani, Efstathios Chronopoulos

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PubMed Full text at PMC Publisher
In one paragraph

Review in Mediterranean journal of rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michail I KrikelisLaboratory for the Research of Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Athens, Greece.
Dimitra MoschouRheumatologist, Larnaka, Cyprus.
Konstantina ZoupidouAttikon University Hospital, Rheumatology and Clinical Immunology Unit, 4th University Clinic of Internal Medicine, Athens, Greece.
Evangelia MoleRheumatology Department, KAT General Hospital, Athens, Greece.
Konstantinos MakrisDepartment of Biochemistry, KAT General Hospital, Athens, Greece.
Simeon TournisLaboratory for the Research of Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Athens, Greece.
Sousana GaziRheumatology Department, KAT General Hospital, Athens, Greece.
Vassilios Nikolaou2nd University Clinic of Orthopaedic Surgery, Konstantopoulio General Hospital, Athens, Greece.
Clio MavraganiLaboratory of Experimental Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Efstathios ChronopoulosLaboratory for the Research of Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Greece, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction and Methods: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by bone loss. A Medline/PubMed search was conducted in September 2025 using the keywords "rheumatoid arthritis" AND "bone loss." The search was restricted to recently published review or systematic review articles (2020-2025). In total, 24 articles were thoroughly reviewed. Results: Inflammation-induced accelerated bone resorption both at the systemic level and in juxta-articular bone is typical to rheumatoid arthritis. Bone formation and bone biomechanics are also impaired due to inflammation, prolonged or repeated corticosteroid treatment, and muscle wasting. Conclusions: Aberrant bone loss and impaired bone formation are hallmarks of rheumatoid arthritis. The underlying pathophysiological mechanisms differ between early and refractory disease, suggesting a potential central role of the highly conserved Wnt pathway in the bone impairment observed in established RA.

Indexed as

bone lossrheumatoid arthritisWnt pathway

Identifiers

PMID42756671
PMCPMC13583214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.