Evidence map›Paper›PMID 42756602›Full record

ArticleiScience2026

Single-cell gene regulatory networks characterize colonic stem and immune cell homeostasis in

Selim Romero, Shreyan Gupta, Michael L Salinas, Destiny A Mullens, Jennifer Goldsby, Yang Y Fan, Laurie A Davidson, Jaileen Rivera-Rodriguez, Gus A Wright, Stephen H Safe and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Selim RomeroDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Shreyan GuptaDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Michael L SalinasDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Destiny A MullensDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.
Jennifer GoldsbyDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Yang Y FanDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Laurie A DavidsonDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Jaileen Rivera-RodriguezDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Gus A WrightDepartment of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA.
Stephen H SafeDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.
James J CaiDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Robert S ChapkinDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.

Funding

Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Weston W Porter · 2019 to 2026
$13.0M
NR4A1 Antagonists Inhibit Colorectal Cancer Growth and Enhance Immune SurveillanceR01CA269580 · NCI · TEXAS A&M UNIVERSITY · PI MAEN ABDELRAHIM, James Jing Cai · 2023 to 2026
$2.3M
NCI NIH HHS R01 CA269580NIEHS NIH HHS P30 ES029067
6 · The paper itself

Abstract

Recent findings suggest that the orphan nuclear receptor 4A (NR4A) can regulate cellular energetics and epithelial defenses, contributing to a resilient, disease-resistant phenotype. To further examine the effects of NR4A on intestinal epithelial, stromal, and immune cell homeostasis, we performed single-cell transcriptomics and differential gene network analysis in wild-type and whole-body

Indexed as

differentiation potencyentropygene regulatory networksimmune cellsintestineorganoidsstem cells

Identifiers

PMID42756602
PMCPMC13583975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.