ArticleBiomaterials research2026
A Glutathione-Responsive Prodrug Nanosystem for Colorectal Cancer: Synergistic Co-Delivery of Paclitaxel and Curcumin to Combat Multidrug Resistance and Reinvent the Immunosuppressive Microenvironment.
Article in Biomaterials research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The management of colorectal cancer is constrained by a self-perpetuating vicious cycle, driven initially by gut microbiota dysbiosis that triggers chronic inflammation, which in turn promotes the establishment of an immunosuppressive tumor microenvironment and multidrug resistance. We engineered a glutathione (GSH)-responsive prodrug micellar nanosystem (PSC/PTX) for the synergistic co-delivery of paclitaxel (PTX) and curcumin (CUR). In this nanoplatform, CUR was covalently conjugated to form a prodrug via disulfide linkages, while PTX was physically encapsulated within the micelles, ensuring the precise release of the 2 drugs in the tumor-specific microenvironment. The nanoplatform reverses P-glycoprotein-mediated drug efflux, prolongs the circulation time, improves the bioavailability, and enhances the accumulation at tumor sites of 2 drugs. This nanoplatform exerts multifaceted therapeutic efficacy. Initially, it reinstates the balance of intestinal microbiota by increasing the abundances of beneficial microorganisms (e.g.,
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