Evidence map›Paper›PMID 42756552›Full record

ArticleBrain communications2026

Metabolic alterations in the absence of a neuromuscular phenotype in humanized

David Thompson, Chloe Williams, Georgia Price, Andrew P Tosolini, Clemens Falker-Gieske, Jonathan D Gilthorpe, Giampietro Schiavo, Elizabeth M C Fisher, Thomas J Cunningham

Abstract read
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David ThompsonMary Lyon Centre at MRC Harwell, Harwell OX11 0RD, UK.
Chloe WilliamsDepartment of Medical and Translational Biology, Faculty of Medicine, Umeå University, Umeå 901 87, Sweden.
Georgia PriceMary Lyon Centre at MRC Harwell, Harwell OX11 0RD, UK.
Andrew P TosoliniUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-7651-7442
Clemens Falker-GieskeDepartment of Animal Sciences, Georg-August-University, Göttingen 37077, Germany.
Jonathan D GilthorpeDepartment of Medical and Translational Biology, Faculty of Medicine, Umeå University, Umeå 901 87, Sweden.
Giampietro SchiavoUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-4319-8745
Elizabeth M C FisherMary Lyon Centre at MRC Harwell, Harwell OX11 0RD, UK.ORCID https://orcid.org/0000-0003-2850-9936
Thomas J CunninghamMary Lyon Centre at MRC Harwell, Harwell OX11 0RD, UK.ORCID https://orcid.org/0000-0002-4751-3140

Funding

Wellcome Trust
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis caused by mutations in

Indexed as

ALSgene targetingmouse modelsSOD1

Identifiers

PMID42756552
PMCPMC13583902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.