Evidence map›Paper›PMID 42756486›Full record

ArticleMedComm2026

Improvements With Tiotropium Maintenance Therapy in COPD Patients Without Dyspnea.

Zihui Wang, Junfeng Lin, Guannan Cai, Fan Wu, Zhishan Deng, Qi Wan, Gaoying Tang, Cuiqiong Dai, Lifei Lu, Kunning Zhou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zihui Wang *State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Junfeng Lin *State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Guannan Cai *State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Fan WuState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.ORCID https://orcid.org/0000-0003-0720-4674
Zhishan DengState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Qi WanState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Gaoying TangState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Cuiqiong DaiState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Lifei LuState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Kunning ZhouState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Xiaohui WuState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.ORCID https://orcid.org/0000-0002-9856-6912
Suyin HuangState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Fangyan WuState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Nanshan ZhongState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Yumin ZhouState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Pixin RanState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center For Respiratory Medicine & Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations emphasize symptom-driven management, which may limit the use of maintenance bronchodilator therapy in patients without dyspnea. In this exploratory post hoc analysis of the tiotropium in early-stage chronic obstructive pulmonary disease (Tie-COPD) trial, we assessed tiotropium in 305 patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) and a modified Medical Research Council dyspnea score of 0 (157 tiotropium, 148 placebo). Over 2 years, tiotropium maintained a higher pre-bronchodilator forced expiratory volume in 1 s (FEV

Indexed as

chronic obstructive pulmonary diseaseclinically important deteriorationexacerbationslung functionnon‐dyspneictiotropium

Identifiers

PMID42756486
PMCPMC13583477

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.