ArticleFrontiers in immunology2026
Multimodal MRI links gray matter volume loss and temporal lobe susceptibility to CSF immunological profiles in Guillain-Barré syndrome.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Guillain-Barré syndrome (GBS) is an acute immune-mediated disease of the peripheral nervous system, with accumulating evidence of increased levels of multiple inflammatory factors in the central nervous system. Previous studies have suggested that inflammatory factors may mediate changes in brain structure and function by activating glial cells and altering the expression of iron-regulatory proteins. However, direct imaging evidence supporting these alterations in GBS remains limited. Therefore, based on multimodal magnetic resonance imaging, this study preliminarily investigated potential changes in gray matter structure and iron metabolism in GBS, and further explored their associations with fluid biomarkers. Methods: A total of 25 GBS patients and 39 healthy controls were enrolled and underwent multimodal brain MRI examinations. Voxel-based morphometry (VBM) was used to assess differences in whole-brain gray matter volume (GMV), while quantitative susceptibility mapping (QSM) was used to evaluate tissue magnetic susceptibility. For exploratory analyses, mean GMV and magnetic susceptibility values were extracted from significant whole-brain clusters and correlated with blood and cerebrospinal fluid (CSF) indicators in GBS patients. Results: GBS patients exhibited reduced GMV in the bilateral hippocampal-parahippocampal-amygdala regions and increased magnetic susceptibility in bilateral temporal regions. Exploratory analyses revealed negative associations between GMV in the left hippocampal cluster and several CSF markers involving IgA, IgG, and the CSF-to-serum total protein ratio. Conclusion: GBS patients exhibit potential alterations in brain GMV and magnetic susceptibility-related tissue properties. These findings suggest that GBS may be accompanied by changes in central brain tissue status, and gray matter abnormalities in the limbic system may be associated with alterations in the CSF immune-metabolic microenvironment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.