ArticleFrontiers in microbiology2026
Transient acceleration of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: This study evaluated the effects of Acanthopanax senticosus aqueous extract (ASAE) on submerged mycelial growth and examined associated transcriptional responses using time-course RNA sequencing, weighted gene co-expression network analysis, gene set enrichment analysis, and independent RT-qPCR experiments. Results: Among the concentrations tested, 50 mg/L ASAE produced the greatest biomass accumulation at day 7, increasing mycelial dry weight by 22.7% relative to the untreated control, whereas 1,000 mg/L ASAE inhibited biomass accumulation. However, the treatment effect was no longer statistically significant at day 9, indicating a transient acceleration of biomass accumulation rather than an increase in final biomass yield under the conditions tested. Two-way ANOVA identified significant effects of cultivation time, treatment, and their interaction on mycelial dry weight. WGCNA module eigengenes were further analyzed using models incorporating cultivation time, treatment, and their interaction. MEblue remained significantly associated with all three factors, including their interaction, but was interpreted as a time- and treatment-associated co-expression module rather than a treatment-specific regulatory module. Direction-separated GSEA showed time-resolved enrichment of gene sets related to energy metabolism, RNA processing, protein homeostasis, carbon metabolism, translation, intracellular trafficking, and carbohydrate-associated metabolism. Upregulated GSEA leading-edge genes were intersected with MEblue genes for candidate-gene visualization without performing a second enrichment analysis. Independent RT-qPCR experiments confirmed the expression trends of selected candidates, including Discussion: These findings indicate that ASAE-associated acceleration of
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