Evidence map›Paper›PMID 42756425›Full record

ArticleFrontiers in immunology2026

Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring.

Brittany Jimena, Daniel Kazimierczyk, Simon Kazimierczyk, Haley Moya, Eva Shin, Li Li, Parimal Korgaonkar, Caryn Porter, Brian Seed, Bobby J Cherayil and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Brittany JimenaMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Charlestown, MA, United States.
Daniel KazimierczykMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Charlestown, MA, United States.
Simon KazimierczykMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Charlestown, MA, United States.
Haley MoyaLurie Center for Autism, Mass General for Children, Boston MA, United States.
Eva ShinMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Charlestown, MA, United States.
Li LiCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, United States.
Parimal KorgaonkarCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, United States.
Caryn PorterCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, United States.
Brian SeedCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, United States.
Bobby J CherayilMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Charlestown, MA, United States.
Nitya JainMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Charlestown, MA, United States.

Funding

Maternal Microbial Influences on Early-life Thymic T cell developmentR01AI154626 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, NITYA · 2020 to 2022
$1.5M
Regulation of early life immunity by maternal microchimeric cellsR21AI168518 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, NITYA · 2022 to 2023
$455k
NIAID NIH HHS R01 AI154626NIAID NIH HHS R21 AI168518
6 · The paper itself

Abstract

Vertically transferred maternal cells or maternal microchimeric cells (MMCs) engraft the fetus and persist in offspring for long periods of time. How altered maternal immune states arising from infection affect MMCs and their function in offspring is poorly understood. Here, we show that pregnancy-associated transient maternal infection alters MMCs to differentially regulate immunity in offspring. In male offspring of dams previously infected with

Indexed as

Pregnancy Complications, InfectiousPrenatal Exposure Delayed EffectsYersinia pseudotuberculosisYersinia pseudotuberculosis InfectionsAnimalsChimerismFemaleImmunity, Maternally-AcquiredMaleMaternal-Fetal ExchangeMicePregnancymaternal microchimeric cellspregnancy-associated infectionSalmonella typhimuriumtype 17 effector T cellsvertically transmitted immunity

Identifiers

PMID42756425
PMCPMC13582634

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.