Evidence map›Paper›PMID 42756406›Full record

ArticleFrontiers in bioinformatics2026

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors.

Chita Ranjan Sahoo, Madhusmita Rout, Sudhir Kumar Paidesetty, Budheswar Dehury, Debdutta Bhattacharya, Sanghamitra Pati

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chita Ranjan SahooDepartment of Health Research, ICMR-Regional Medical Research Centre, Ministry of Health and Family Welfare, Government of India, Bhubaneswar, India.
Madhusmita RoutDepartment of Health Research, ICMR-Regional Medical Research Centre, Ministry of Health and Family Welfare, Government of India, Bhubaneswar, India.
Sudhir Kumar PaidesettyMedicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, India.
Budheswar DehuryDepartment of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Debdutta BhattacharyaDepartment of Health Research, ICMR-Regional Medical Research Centre, Ministry of Health and Family Welfare, Government of India, Bhubaneswar, India.
Sanghamitra PatiDepartment of Health Research, ICMR-Regional Medical Research Centre, Ministry of Health and Family Welfare, Government of India, Bhubaneswar, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widespread use of antibiotics, particularly ciprofloxacin, has accelerated the emergence of antibiotic-resistant bacteria, posing a major public health challenge. Limited investment and declining pharmaceutical interest have slowed the discovery of new antibiotics, contributing to the increasing prevalence of multidrug-resistant (MDR) infections, especially those caused by ESKAPE pathogens. Uropathogenic

Indexed as

AMR (antimicrobial resistance)ciprofloxacinmolecular dockingmolecular simulationsulfanilamide

Identifiers

PMID42756406
PMCPMC13582570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.