Evidence map›Paper›PMID 42756394›Full record

ArticleMedComm2026

Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorate NaIO

Zheng Li, Tujing Zhao, Lin Ye, Runze Li, Huaping Tian, Ruilin Liao, Lulin Huang

Abstract read
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zheng Li *The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China.
Tujing Zhao *The Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China.
Lin YeThe Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China.
Runze LiThe Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China.
Huaping TianThe Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China.
Ruilin LiaoThe Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China.
Lulin HuangThe Genetic Diseases Key Laboratory of Sichuan Province The Department of Medical Genetics The Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine, University of Electronic Science and Technology of China Chengdu 610072 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry age-related macular degeneration (AMD), affecting over 196 million people globally, represents the leading cause of irreversible blindness with limited disease-modifying therapies. The disease is characterized by progressive retinal pigment epithelium (RPE) degeneration driven by ferroptosis, an iron-dependent form of regulated cell death. While mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) show therapeutic promise, their mechanisms in counteracting RPE ferroptosis remain unexplored. Here, we prove that human umbilical cord MSC-derived EVs (hucMSC-EVs) significantly attenuate NaIO

Indexed as

dry age‐related macular degenerationextracellular vesiclesferroptosisLipocalin‐2miR‐486‐3pretinal pigment epithelium

Identifiers

PMID42756394
PMCPMC13583448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.