ArticleBioinformatics and biology insights2026
Unravelling Ferroptosis in Sepsis: A Comprehensive Integrative Transcriptomic Analysis Across Age and Disease Severity.
Article in Bioinformatics and biology insights, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Ferroptosis, an iron-dependent, regulated form of cell death, has been increasingly recognised as a pivotal driver of organ dysfunction and mortality in sepsis. Despite its importance, the transcriptomic regulation of ferroptosis in human sepsis has not been systematically characterised. Here, we present a comprehensive integrative analysis, combining 17 transcriptomic data sets from previously published studies involving blood samples from septic patients and healthy controls, encompassing microarray, bulk RNA sequencing, and single-cell RNA sequencing platforms. Our findings reveal that ferroptosis-related gene regulation intensifies with disease progression and is markedly more pronounced in adults. Single-cell analysis identified monocytes as the primary regulators of ferroptosis in peripheral blood during sepsis. Eleven core ferroptosis-related genes (
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