ArticleFrontiers in pharmacology2026
Polysaccharides from the root tubers of
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The root tuber of Methods: A polysaccharide-enriched fraction (CWP) was isolated from Results: CWP was characterized as a mannose- and glucose-rich polysaccharide-enriched fraction (average Mw 5.89 kDa; mannose 47.05 mol%, glucose 33.67 mol%) containing both α- and β-glycosidic configurations. Oral administration of CWP significantly reduced serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bile acids (TBA) at both doses tested, and attenuated hepatocyte necrosis and inflammatory infiltration in ANIT-challenged mice. Mechanistically, CWP upregulated bile acid synthesis enzymes ( Conclusion: CWP alleviates ANIT-induced cholestatic liver injury by restoring hepatic bile acid clearance, selectively remodeling the gut microbiota, and suppressing inflammation across the gut-liver axis. These results support further development of CWP as a functional macromolecule for managing cholestatic liver diseases.
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