Evidence map›Paper›PMID 42756234›Full record

ArticleAffective science2026

Amygdalar Pattern Similarity to Negative and Neutral Images, Ratings of the Images, and PET-Measured Amyloid and Tau Levels in Older Adults Without Dementia.

Mingtong Liu, Lauren K Gresham, Nikki A Puccetti, Tobey J Betthauser, Sterling C Johnson, Stacey M Schaefer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Affective science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingtong LiuInstitute on Aging, University of Wisconsin-Madison, Madison, WI 53706 USA.ORCID 0000-0002-1884-3212
Lauren K GreshamInstitute on Aging, University of Wisconsin-Madison, Madison, WI 53706 USA.ORCID 0000-0003-0688-0558
Nikki A PuccettiThe Ohio State University, Columbus, OH 43210 USA.ORCID 0000-0001-9841-0718
Tobey J BetthauserWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, MC 2420, 600 Highland Avenue, Madison, WI 53792-2420 USA.ORCID 0000-0001-8856-1352
Sterling C JohnsonInstitute on Aging, University of Wisconsin-Madison, Madison, WI 53706 USA.ORCID 0000-0002-8501-545X
Stacey M SchaeferInstitute on Aging, University of Wisconsin-Madison, Madison, WI 53706 USA.ORCID 0000-0003-4539-7219

Funding

The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Neural and facial EMG correlates of the temporal dynamics of emotion in preclinical AD: Relations with emotional memory, cognition, and tau and amyloid burden in brain regions underlying emotionR21MH113227 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI SCHAEFER, STACEY M · 2017 to 2018
$421k
NIA NIH HHS R01 AG021155NICHD NIH HHS P50 HD105353NIMH NIH HHS R21 MH113227
6 · The paper itself

Abstract

This study examines associations between brain levels of amyloid-β and tau with representational pattern similarity in amygdalar reactivity to negative and neutral images in older adults without dementia. 81 participants viewed affective images during functional magnetic resonance imaging (fMRI). Participants rated the images on valence and arousal outside the scanner. Amyloid-β and tau were measured with Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s42761-026-00394-5.

Indexed as

Alzheimer’s diseaseAmygdalaEmotional reactivityfMRIRepresentational similarity analysisTau

Identifiers

PMID42756234
PMCPMC13582699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.